Multiple studies are ongoing and there are some studies that have reported promising results.
Ivermectin is a member of the macrocylic lactone class of endectocides which have a unique mode of action, Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.
What are the side effects of Ivermectin?
Ivermectin is well tolerated compared to other microfilaricidal agents. The side effects may go away during treatment as your body adjusts to the medicine.
Before taking this medication, tell your doctor if you've had liver problems
- Increase of liver enzymes
- Increase of bilirubin in blood
- Increase of eosinophils
- Low blood pressure (hypotension).
- You may feel dizzy or light-headed when standing up
- Worsening of asthma.
- Loss of appetite Dizziness
How should I take Ivermectin?
Follow the directions on your prescription label carefully and ask your doctor or pharmacist for more information It is usually taken as a single dose on an empty stomach with a full glass of water. A recent pharmacokinetics study reports that following a high-fat meal absorption was significantly higher (about 2.5 times) than in the fasted state.
Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention if you are taking medications for anxiety, mental illness or seizures; muscle relaxants; sedatives; sleeping pills; or tranquilizers.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
What happens if I drink alcohol while taking ivermectin?
Using alcohol with ivermectin can increase blood levels or add to the side effects of ivermectin. This can cause skin rash, swelling, headache, dizziness, weakness, nausea, vomiting, diarrhea, stomach pain, seizure (convulsions), shortness of breath, and numbness or tingling.
Does Ivermectin interact with any other medications?
Products that may interact with Ivermectin include:
- Barbiturates (such as phenobarbital, butalbital)
- Benzodiazepines (such as clonazepam, lorazepam)
- Sodium oxybate (GHB)
- Valproic acid